Institutional Ownership
Upstream Bio Inc
CUSIP 91678A107COMUPBQ1 2026
13D / 13G Filings
12
Schedule 13D/13G on record
Beneficial Filers
8
Distinct reporting persons
Largest Stake
14.8%
Max % of class reported
Institutional Holders
133
13F filers (latest quarter)
Beneficial Owners — Schedule 13D / 13G
12 filings · latest Nov 14, 2025
| # | Filed | Reporting Person | Form | % of Class | Shares | Filing |
|---|---|---|---|---|---|---|
| 1 | Nov 14, 2025 | Tcg Crossover Gp I, LLC | 13G/A | 11.0% | 2.12M | SEC |
| 2 | Nov 14, 2025 | Hbm Healthcare Investments (Cayman) Ltd. | 13G/A | 4.1% | 2.20M | SEC |
| 3 | Oct 24, 2025 | Norges Bank | 13G | 5.3% | 2.88M | SEC |
| 4 | Aug 6, 2025 | Fmr LLC | 13G/A | 14.8% | 7.94M | SEC |
| 5 | Feb 14, 2025 | Decheng Capital Global Life Sciences Fund IV, L.P. | 13G | 6.1% | 3.29M | SEC |
| 6 | Feb 14, 2025 | Tcg Crossover Gp I, LLC | 13G | 11.0% | 2.80M | SEC |
| 7 | Feb 13, 2025 | Hbm Healthcare Investments (Cayman) Ltd. | 13G | 5.1% | 2.72M | SEC |
| 8 | Feb 12, 2025 | Fmr LLC | 13G/A | 13.4% | 7.18M | SEC |
| 9 | Nov 7, 2024 | Fmr LLC | 13G | 11.8% | — | SEC |
| 10 | Oct 22, 2024 | Ai Upstream LLC | 13D | 10.7% | 5.49M | SEC |
2 more beneficial-ownership filings on Premium
See the full Schedule 13D/13G history for Upstream Bio Inc.
Unlock full historyTop Institutional Holders (13F)
Largest reported positions · latest quarter
| # | Fund | Shares | Value |
|---|---|---|---|
| 1 | Fmr LLC | 8.10M | $72.91M |
| 2 | Orbimed Advisors LLC | 5.69M | $51.24M |
| 3 | Blackrock, Inc. | 3.37M | $30.34M |
| 4 | Decheng Capital LLC | 2.72M | $24.52M |
| 5 | Enavate Sciences Gp, LLC | 2.46M | $22.14M |
| 6 | Y-Intercept (Hong Kong) Ltd | 1.00M | $9.01M |
| 7 | Federated Hermes, Inc. | 979.8K | $8.82M |
| 8 | Geode Capital Management, LLC | 950.6K | $8.56M |
| 9 | Millennium Management LLC | 937.3K | $8.44M |
| 10 | Seb Asset Management Ab | 878.5K | $7.91M |