Institutional Ownership
Upstream Bio Inc
CUSIP 91678A107COMUPBQ1 2026
Institutional Holders
133
13F filers
Shares Held
41.94M
Aggregate institutional
Institutional Value
$377.39M
Q1 2026
Net New Holders
+3
40 new · 37 closed
Institutional Ownership Trend
Aggregate 13F value by quarter
Multi-quarter trend — upgrade to see history
UpgradePosition Activity
Q1 2026
New positions40
Increased46
Decreased35
Sold out37
Institutional Holders
133 funds hold this security · Q1 2026
| # | Fund | Shares | Value | Δ Shares | Activity |
|---|---|---|---|---|---|
| 1 | Fmr LLC | 8.10M | $72.91M | +583.4K | Added |
| 2 | Orbimed Advisors LLC | 5.69M | $51.24M | 0 | Held |
| 3 | Blackrock, Inc. | 3.37M | $30.34M | +26.2K | Added |
| 4 | Decheng Capital LLC | 2.72M | $24.52M | −418.2K | Reduced |
| 5 | Enavate Sciences Gp, LLC | 2.46M | $22.14M | 0 | Held |
| 6 | Y-Intercept (Hong Kong) Ltd | 1.00M | $9.01M | +954.1K | Added |
| 7 | Federated Hermes, Inc. | 979.8K | $8.82M | +979.3K | Added |
| 8 | Geode Capital Management, LLC | 950.6K | $8.56M | +98.7K | Added |
| 9 | Millennium Management LLC | 937.3K | $8.44M | +420.1K | Added |
| 10 | Seb Asset Management Ab | 878.5K | $7.91M | +878.5K | First Filing |
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