Institutional Ownership
Spyre Therapeutics Inc
CUSIP 00773J202COM NEWSYREQ1 2026
13D / 13G Filings
42
Schedule 13D/13G on record
Beneficial Filers
23
Distinct reporting persons
Largest Stake
18.2%
Max % of class reported
Institutional Holders
190
13F filers (latest quarter)
Beneficial Owners — Schedule 13D / 13G
42 filings · latest Feb 17, 2026
| # | Filed | Reporting Person | Form | % of Class | Shares | Filing |
|---|---|---|---|---|---|---|
| 1 | Feb 17, 2026 | Tang Capital Management, LLC | 13G/A | 2.4% | 1.89M | SEC |
| 2 | Oct 17, 2025 | Fairmount Funds Management LLC | 13D/A | 10.0% | — | SEC |
| 3 | Jul 29, 2025 | The Vanguard Group | 13G | 5.1% | 3.07M | SEC |
| 4 | Jul 16, 2025 | Blackrock, Inc. | 13G/A | 6.6% | 3.96M | SEC |
| 5 | May 1, 2025 | Tang Capital Management, LLC | 13G | 5.3% | 3.20M | SEC |
| 6 | Feb 14, 2025 | Venrock Healthcare Capital Partners III, L.P. | 13G/A | 4.6% | 2.69M | SEC |
| 7 | Feb 14, 2025 | Perceptive Advisors LLC | 13G/A | 4.4% | 2.57M | SEC |
| 8 | Feb 14, 2025 | Rtw Investments, LP | 13G/A | 6.2% | 3.62M | SEC |
| 9 | Nov 14, 2024 | Commodore Capital LP | 13G/A | 3.9% | 1.99M | SEC |
| 10 | Nov 14, 2024 | Perceptive Advisors LLC | 13G/A | 5.7% | 2.87M | SEC |
32 more beneficial-ownership filings on Premium
See the full Schedule 13D/13G history for Spyre Therapeutics Inc.
Unlock full historyTop Institutional Holders (13F)
Largest reported positions · latest quarter
| # | Fund | Shares | Value |
|---|---|---|---|
| 1 | Fmr LLC | 11.78M | $594.23M |
| 2 | Blackrock, Inc. | 5.52M | $278.49M |
| 3 | Rtw Investments, LP | 4.17M | $210.44M |
| 4 | Fairmount Funds Management LLC | 4.02M | $202.67M |
| 5 | Perceptive Advisors LLC | 3.78M | $190.83M |
| 6 | Venrock Adviser, LLC | 3.69M | $185.89M |
| 7 | Driehaus Capital Management LLC | 2.79M | $140.77M |
| 8 | State Street Corp | 2.61M | $131.50M |
| 9 | Paradigm Biocapital Advisors LP | 1.96M | $98.72M |
| 10 | Commodore Capital LP | 1.91M | $96.46M |