Institutional Ownership
Spyre Therapeutics Inc
CUSIP 00773J202COM NEWSYREQ1 2026
Institutional Holders
190
13F filers
Shares Held
78.38M
Aggregate institutional
Institutional Value
$3.86B
Q1 2026
Net New Holders
+42
53 new · 11 closed
Institutional Ownership Trend
Aggregate 13F value by quarter
Multi-quarter trend — upgrade to see history
UpgradePosition Activity
Q1 2026
New positions53
Increased65
Decreased48
Sold out11
Institutional Holders
190 funds hold this security · Q1 2026
| # | Fund | Shares | Value | Δ Shares | Activity |
|---|---|---|---|---|---|
| 1 | Fmr LLC | 11.78M | $594.23M | +142.2K | Added |
| 2 | Blackrock, Inc. | 5.52M | $278.49M | −880 | Reduced |
| 3 | Rtw Investments, LP | 4.17M | $210.44M | 0 | Held |
| 4 | Fairmount Funds Management LLC | 4.02M | $202.67M | 0 | Held |
| 5 | Perceptive Advisors LLC | 3.78M | $190.83M | +714.0K | Added |
| 6 | Venrock Adviser, LLC | 3.69M | $185.89M | 0 | Held |
| 7 | Driehaus Capital Management LLC | 2.79M | $140.77M | −91.6K | Reduced |
| 8 | State Street Corp | 2.61M | $131.50M | +344.2K | Added |
| 9 | Paradigm Biocapital Advisors LP | 1.96M | $98.72M | +490.0K | Added |
| 10 | Commodore Capital LP | 1.91M | $96.46M | −475.9K | Reduced |
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